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In a NASA study of young male bodybuilders, boron supplementation had no effect on blood testosterone levels or lean body mass Green and Ferrando, Boric acid does not exhibit the properties or characteristics of hormones, including estrogens and androgens.

Link to relevant study record s Description of key information The data indicates that any endocrine effects are secondary to germ cell changes and that boric acid does not bind directly to the estrogen receptor.

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The structure of boric acid is fundamentally different from the multi-ringed chemical structures that are min și weir dating often found to be estrogenic. Additional information No data is available for diammonium decaborate, however, since all the borates will exist as undissociated boric acid under physiological and environmental conditions, the toxicology of all these simple borates is similar on an equivalent boric acid basis or boron basis.

Boric acid does not exhibit the properties or characteristics of hormones, including estrogens and vmi dating. Several studies have evaluated possible endocrine effects of boron compounds Wang et al.

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The data indicates that any endocrine effects are secondary to germ cell changes since histologic changes occurred by Day 7 while peripheral hormone changes were not detected before Day 14 of treatment Fail et al. Boric acid-induced testicular toxicity in rodents appears to be due to a direct effect on Sertoli cells not an effect on the endocrine system.

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Boric acid was not carcinogenic in either mice NTP, or rats Weir min și weir dating Fisher, ; endocrine-disrupting substances typically produce hormonally-related tumors in chronic toxicity studies in animals.

Boric acid was negative in a yeast two-hybrid estrogenicity assay, indicating that boric acid does not bind directly to the estrogen receptor and mimic endogenous estrogen Nishihara et al Boric acid may be too small molecularly to interact with the estrogen receptor or other steroid hormone receptors.

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Conflicting evidence of estrogenic activity was observed in a battery of short-term in vitro and in vivo studies Wang et al. In comparison, boric acid did not stimulate the proliferation of MCF-7 human breast cancer cells Wang et al.

No evidence of hormonally-related clinical symptoms have been reported in workers exposed to boric acid Whorton et al. In contrast, decreases in serum 17b-estradiol and progesterone were reported in another study of postmenopausal women given 3.

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In autoritatea de dating internet NASA study of young male bodybuilders, boron supplementation had no effect on blood testosterone levels or lean body mass Green and Ferrando, Epidemiological, animal, and cell culture studies have identified boric acid as a chemopreventative agent in prostate cancer Cui et al.

Although estrogens are frequently used to treat prostate cancer, the chemopreventative effects of boric acid on prostate cancer appear to have a non-endocrine mode of action. Similarly, Barranco et al. Read Across A number of these studies were conducted on an analogue substance.

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Read-across is justified min și weir dating the following basis: In aqueous solutions at physiological and acidic pH, low concentrations of simple inorganic borates such as boric acid, diammonium decaborate, min și weir dating tetraborate pentahydrate, boric oxide and disodium octaborate tetrahydrate will predominantly exist as undissociated boric acid. This leads to the conclusion that the main species in the plasma of mammals and in the environment is un-dissociated boric acid.

Since other borates dissociate to form boric acid in aqueous solutions, they too can be considered to exist as un-dissociated boric acid under the same conditions. For comparative purposes, exposures to borates are often expressed in terms of boron B equivalents based on the fraction of boron in the source substance on a molecular weight basis.

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Some studies express dose in terms of B, whereas other studies express the dose in units of boric acid. Since the systemic effects and some of the local effects can be traced back to boric acid, results min și weir dating one substance can be transferred to also evaluate the another substance on the basis of boron equivalents.

Therefore data obtained from studies with these borates can be read across in the human health assessment for each individual substance.

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Conversion factors are given in the table under CSR section 5. References: WHO. Guidelines for drinking-water quality, Addendum to Volume 1, Information on Registered Substances comes from registration dossiers which have been assigned a registration number.

This information has not been reviewed or verified by the Agency or any other authority.

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